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KMID : 0371619990150020205
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Journal of Wonkwang Medical Science
1999 Volume.15 No. 2 p.205 ~ p.210
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Postoperative Radiotherapy for Squamous Cell Carcinomas of the Oral Cavity
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Moon Sun-Rock
Garden Adam S
Ang K. Kian
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Abstract
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Purpose: The purpose of this study was to determine the impact of anatomic subsite on the results of treatment with oral cavity cancers.
Methods: Between 1970 and 1994, 284 patients with squamous cell carcinoma of the oral tongue (162 patients) and floor of mouth (122 patients) were treated with surgery followed by postoperative radiotherapy. All had an indication(s) for radiotherapy including advanced primary disease, close or positive margin, and multiple positive neck nodes and/or extracapsular extension.
Results: The 5-year actuarial local control rate was 77.1% for oral tongue vs. 67.5% for floor of mouth(p = 0.03). The 5-year actuarial neck control rate was 76.0% for oral tongue vs. 82.3% for floor of mouth(p = 0.06). The 5-year actuarial disease-free survival rate was 54% for oral tongue vs. 48% for floor of mouth(p = 0.34). The 5-year actuarial overall survival was 40.9% for oral tongue vs. 33.6% for floor of mouth(p = 0.3).
Conclusions: This study showed significant differences in local control between floor of mouth and oral tongue cancers in response to surgery and postoperative radiotherapy. Future strategies should be directed at the improvement of local control for floor of mouth and better systemic therapy for those with advanced N-stage.
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KEYWORD
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Postoperative raitherapy, Sqyamous cell carcinoma, Oral cavity
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